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ea0026p343 | Obesity | ECE2011

3-iodothyronamine metabolism and metabolic effects in rat white adipocytes

Manni M E , Bigagli E , Saba A , Marchini M , Zucchi R , Raimondi L

Introduction: 3-Iodothyronamine (T1AM) is a novel thyroid hormone derivative, which has been detected in rat blood and tissues. In vivo, T1AM has been reported to produce several functional effects, including the switch of fuel utilization from carbohydrates to lipids. In the present work we used rat white adipocytes to investigate T1AM uptake, metabolism, and metabolic effects.Methods: Rat white adipocytes were incubated with exogenous T1AM. The ...

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ea0029p700 | Diabetes | ICEECE2012

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

Dicembrini I. , Di Pasquale G. , Raimondi L. , Pagano C. , Egan J. , Cozzi A. , Cinci L. , Manni E. , Loreto A. , Berretti S. , Morelli A. , Baum B. , Maggi M. , Vettor R. , Chiorini J. , Rotella C. , Mannucci E.

Background: Exendin-4 (Ex-4) is a GLP-1 receptor agonist approved for the treatment of Type 2 Diabetes (T2DM). Aim of this study was to characterize the effects of Ex-4 expressed continuously from salivary glands (SG), following adeno-associated virus-mediated (AAV) gene therapy in two different model of obesity and T2DM. Several trials support an AAV good safety and little toxicity profile. Serotype 5 (AAV5) presented enhanced gene transfer activity in SG and an efficient pro...

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Endocrine Abstracts

3-iodothyronamine metabolism and metabolic effects in rat white adipocytes

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

BiosciAbstracts